What is tryptophan? Tryptophan is an essential amino acid in the human body. It functions as a biochemical precursor to sleep inducing compounds serotonin and melatonin. This tryptophan amino acid is not naturally produced in the body therefore It has to come from our diet. Eating foods high in tryptophan are known to promote calmness or feelings of lethargy. A tryptophan deficiency may lead to low levels of serotonin. Low serotonin levels are associated with depression, anxiety, irritability, impatience, impulsiveness, inability to concentrate, weight gain, overeating, carbohydrate cravings, poor dream recall, and insomnia. Vitamin B6 is necessary for the conversion of tryptophan to serotonin. Consequently, a dietary deficiency of vitamin B6 may result in low serotonin levels and/or impaired conversion of tryptophan. In addition, several dietary, lifestyle, and health factors reduce the conversion of tryptophan to serotonin, including cigarette smoking, high sugar intake, alcohol abuse, excessive consumption of protein, hypoglycemia and diabetes. Read more »